Protracted withdrawal signs or symptoms may last weeks to greater than twelve months. Due to this fact, there might be problem in differentiating withdrawal signs from likely re-emergence or continuation of signs for which the benzodiazepine was getting used.维基百科中的醫學内容仅供参考，並不能視作專業意見。如需獲取醫�

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Omtrent seven-9 % af den kaukasiske befolkning har variationer i CYP2D6 genet som koder for ingen- eller nedsat aktivitet af CYP2D6 (se personlig medicin ). Tramadol et produg der omdannes til den aktive metabolit through CYP2D6. Patienter med nedsat eller manglende aktivitet af CYP2D6, vil have reduceret- eller manglende effekt af tramadol.Ekspert